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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50020084
Substrate
n/a
Meas. Tech.
ChEMBL_1363771 (CHEMBL3294188)
IC50
>10000±n/a nM
Citation
 Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett 5:544-9 (2014) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50020084
Synonyms:
CHEMBL3287879
Type:
Small organic molecule
Emp. Form.:
C30H30N2O6
Mol. Mass.:
514.569
SMILES:
OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1C(O)=O |r,wU:7.10,wD:4.3,(24.43,-3.81,;23.11,-4.61,;21.76,-3.87,;23.15,-6.15,;21.84,-6.95,;20.48,-6.21,;19.17,-7.01,;19.21,-8.55,;20.56,-9.29,;21.87,-8.49,;17.89,-9.35,;16.54,-8.61,;15.23,-9.41,;15.27,-10.95,;16.62,-11.69,;17.93,-10.89,;13.95,-11.75,;13.99,-13.29,;12.68,-14.09,;11.32,-13.35,;10.01,-14.15,;8.66,-13.41,;8.62,-11.87,;9.94,-11.07,;11.29,-11.81,;12.6,-11.01,;10.05,-15.69,;11.39,-16.42,;8.73,-16.49,;8.77,-18.02,;10.12,-18.76,;10.15,-20.29,;8.84,-21.09,;7.49,-20.36,;7.45,-18.82,;6.1,-18.08,;6.06,-16.54,;4.78,-18.88,)|
Structure:
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