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Target
Adenosine kinase
Ligand
BDBM50350207
Substrate
n/a
Meas. Tech.
ChEMBL_1439143 (CHEMBL3385544)
IC50
200±n/a nM
Citation
 Sná?el, J; Nau?, P; Dostál, J; Hnízda, A; Fanfrlík, J; Brynda, J; Bourderioux, A; Du?ek, M; Dvoráková, H; Stolaríková, J; Zábranská, H; Pohl, R; Konecný, P; D?ubák, P; Votruba, I; Hajdúch, M; Rezácová, P; Veverka, V; Hocek, M; Pichová, I Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides. J Med Chem 57:8268-79 (2014) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50350207
Synonyms:
CHEMBL1814776
Type:
Small organic molecule
Emp. Form.:
C13H14N4O4
Mol. Mass.:
290.2747
SMILES:
Nc1ncnc2n(cc(C#C)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure:
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