Target
Lysosomal alpha-mannosidase
Ligand
BDBM50242271
Substrate
n/a
Meas. Tech.
ChEMBL_1432452 (CHEMBL3385734)
IC50
379000±n/a nM
Citation
 Markad, PRSonawane, DPGhosh, SChopade, BAKumbhar, NLouat, THerman, JWaer, MHerdewijn, PDhavale, DD ¿-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents. Bioorg Med Chem 22:5776-82 (2014) [PubMed]  Article 
Target
Name:
Lysosomal alpha-mannosidase
Synonyms:
LAMAN | MA2B1_HUMAN | MAN2B1 | MANB
Type:
PROTEIN
Mol. Mass.:
113753.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1432452
Residue:
1011
Sequence:
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
  
Inhibitor
Name:
BDBM50242271
Synonyms:
(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3R,4R,5S)-1-ethoxy-2-(hydroxymethyl)piperidine-3,4,5-triol | BAY-M-1099 | CHEMBL1561 | Glyset | MIGLITOL | N-Hydroxyethyl-1-deoxynojirimycin | cid_441314
Type:
Small organic molecule
Emp. Form.:
C8H17NO5
Mol. Mass.:
207.2243
SMILES:
OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r|
Structure:
Search PDB for entries with ligand similarity: