Reaction Details
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Bcl-2-like protein 1
Ligand
BDBM50030749
Substrate
n/a
Meas. Tech.
ChEMBL_1437734 (CHEMBL3382381)
Ki
0.340000±n/a nM
Citation
Tao, ZF; Hasvold, L; Wang, L; Wang, X; Petros, AM; Park, CH; Boghaert, ER; Catron, ND; Chen, J; Colman, PM; Czabotar, PE; Deshayes, K; Fairbrother, WJ; Flygare, JA; Hymowitz, SG; Jin, S; Judge, RA; Koehler, MF; Kovar, PJ; Lessene, G; Mitten, MJ; Ndubaku, CO; Nimmer, P; Purkey, HE; Oleksijew, A; Phillips, DC; Sleebs, BE; Smith, BJ; Smith, ML; Tahir, SK; Watson, KG; Xiao, Y; Xue, J; Zhang, H; Zobel, K; Rosenberg, SH; Tse, C; Leverson, JD; Elmore, SW; Souers, AJ Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett 5:1088-93 (2014) [PubMed] Article More Info.:
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Inhibitor
Name:
BDBM50030749
Synonyms:
CHEMBL3342190
Type:
Small organic molecule
Emp. Form.:
C35H28N8O4S2
Mol. Mass.:
688.778
SMILES:
OC(=O)c1nc(sc1CCCOc1cccc(c1)-n1ncc2cncnc12)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
Structure:
