Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Apoptosis regulator Bcl-2
Ligand
BDBM50030757
Substrate
n/a
Meas. Tech.
ChEMBL_1437736 (CHEMBL3382383)
Ki
140±n/a nM
Citation
Tao, ZF; Hasvold, L; Wang, L; Wang, X; Petros, AM; Park, CH; Boghaert, ER; Catron, ND; Chen, J; Colman, PM; Czabotar, PE; Deshayes, K; Fairbrother, WJ; Flygare, JA; Hymowitz, SG; Jin, S; Judge, RA; Koehler, MF; Kovar, PJ; Lessene, G; Mitten, MJ; Ndubaku, CO; Nimmer, P; Purkey, HE; Oleksijew, A; Phillips, DC; Sleebs, BE; Smith, BJ; Smith, ML; Tahir, SK; Watson, KG; Xiao, Y; Xue, J; Zhang, H; Zobel, K; Rosenberg, SH; Tse, C; Leverson, JD; Elmore, SW; Souers, AJ Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett 5:1088-93 (2014) [PubMed] Article More Info.:
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Inhibitor
Name:
BDBM50030757
Synonyms:
CHEMBL3342196
Type:
Small organic molecule
Emp. Form.:
C43H45N11O4S2
Mol. Mass.:
844.019
SMILES:
CN1CCN(CCCNc2ncnc3n(ncc23)-c2ccc(OCCCc3sc(nc3C(O)=O)N3CCc4cccc(C(=O)Nc5nc6ccccc6s5)c4C3)cc2)CC1
Structure:
