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Target
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Ligand
BDBM92459
Substrate
n/a
Meas. Tech.
ChEMBL_1432745 (CHEMBL3390549)
IC50
59000±n/a nM
Citation
 Seelhorst, K; Piernitzki, T; Lunau, N; Meier, C; Hahn, U Synthesis and analysis of potentiala1,3-fucosyltransferase inhibitors. Bioorg Med Chem 22:6430-7 (2014) [PubMed]  Article 
Target
Name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Synonyms:
Alpha-(1,3)-fucosyltransferase 9 | FUT9 | FUT9_HUMAN | Fuc-TIX | FucT-IX | Fucosyltransferase 9 | Fucosyltransferase IX | Galactoside 3-L-fucosyltransferase
Type:
PROTEIN
Mol. Mass.:
42078.14
Organism:
Homo sapiens (Human)
Description:
ChEMBL_10775
Residue:
359
Sequence:
MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWIFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
  
Inhibitor
Name:
BDBM92459
Synonyms:
CHEMBL384759 | GDP | Guanosine Diphosphate
Type:
Small molecule
Emp. Form.:
C10H15N5O11P2
Mol. Mass.:
443.2005
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Structure:
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