Target
Cathepsin D
Ligand
BDBM50036588
Substrate
n/a
Meas. Tech.
ChEMBL_1433719 (CHEMBL3386390)
Ki
>100000±n/a nM
Citation
 Caldwell, JPMazzola, RDDurkin, JChen, JChen, XFavreau, LKennedy, MKuvelkar, RLee, JMcHugh, NMcKittrick, BOrth, PStamford, AStrickland, CVoigt, JWang, LZhang, LZhang, QZhu, Z Discovery of potent iminoheterocycle BACE1 inhibitors. Bioorg Med Chem Lett 24:5455-9 (2015) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50036588
Synonyms:
CHEMBL3353633
Type:
Small organic molecule
Emp. Form.:
C18H32N4O
Mol. Mass.:
320.4729
SMILES:
[H][C@]1(C[C@@]2(CCC3CCCCC3)NC(=N)N(C)C2=O)CCCNC1 |r|
Structure:
Search PDB for entries with ligand similarity: