Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM91551
Substrate
n/a
Meas. Tech.
ChEMBL_1459865 (CHEMBL3367288)
Ki
10000±n/a nM
Citation
 Raghav, N; Singh, M SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H. Bioorg Med Chem 22:4233-45 (2014) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
36777.57
Organism:
Capra hircus (Goat)
Description:
n/a
Residue:
335
Sequence:
MWQLLATLSCLLVLTSARSSLHFPPLSDEMVNYVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADMVLPDSFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSKGRVNVEVSAEDMLTCCGSECGDGCNGGFPSGAWNFWTKKGLVSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPSYKDDKHFGCSSYSVSSNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEMMGGHAIRILGWGVENDTPYWLVGNSWNTDWGDKGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM91551
Synonyms:
3-(4-chlorophenyl)-2,5-diphenyl-3,4-dihydropyrazole | 5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline | VU0466987-1 | cid_248777
Type:
Small organic molecule
Emp. Form.:
C21H17ClN2
Mol. Mass.:
332.826
SMILES:
Clc1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1 |c:10|
Structure:
Search PDB for entries with ligand similarity: