Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50045459
Substrate
n/a
Meas. Tech.
ChEMBL_1447531 (CHEMBL3373138)
IC50
7780±n/a nM
Citation
 Yin, Y; Qiao, F; Jiang, LY; Wang, SF; Sha, S; Wu, X; Lv, PC; Zhu, HL Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors. Bioorg Med Chem 22:4285-92 (2014) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50045459
Synonyms:
CHEMBL3309811
Type:
Small organic molecule
Emp. Form.:
C19H19FN2O3
Mol. Mass.:
342.3642
SMILES:
Oc1ccc(\C=C\C(=O)N2CCN(CC2)c2ccccc2F)cc1O
Structure:
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