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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50045484
Substrate
n/a
Meas. Tech.
ChEMBL_1447540 (CHEMBL3373147)
Ki
43±n/a nM
Citation
 Moritomo, A; Yamada, H; Watanabe, T; Itahana, H; Koga, Y; Akuzawa, S; Okada, M Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2. Bioorg Med Chem 22:4323-37 (2014) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50045484
Synonyms:
CHEMBL3310120
Type:
Small organic molecule
Emp. Form.:
C15H15ClN4O
Mol. Mass.:
302.759
SMILES:
Cl.[#7]-[#6]-1-c2ccccc2-c2ccc(cc-12)-[#6](=O)\[#7]=[#6](/[#7])-[#7]
Structure:
Search PDB for entries with ligand similarity: