Target
Potassium channel subfamily K member 3
Ligand
BDBM50123519
Substrate
n/a
Meas. Tech.
ChEMBL_1457493 (CHEMBL3367860)
IC50
7.0±n/a nM
Citation
 Flaherty, DPSimpson, DSMiller, MMaki, BEZou, BShi, JWu, MMcManus, OBAubé, JLi, MGolden, JE Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett 24:3968-73 (2014) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM50123519
Synonyms:
2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid 2,4-difluoro-benzylamide | CHEMBL148342
Type:
Small organic molecule
Emp. Form.:
C30H26F2N2O3
Mol. Mass.:
500.5358
SMILES:
COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Structure:
Search PDB for entries with ligand similarity: