Target
Potassium channel subfamily K member 3
Ligand
BDBM50050442
Substrate
n/a
Meas. Tech.
ChEMBL_1457493 (CHEMBL3367860)
IC50
130±n/a nM
Citation
 Flaherty, DPSimpson, DSMiller, MMaki, BEZou, BShi, JWu, MMcManus, OBAubé, JLi, MGolden, JE Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett 24:3968-73 (2014) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM50050442
Synonyms:
CHEMBL3186206
Type:
Small organic molecule
Emp. Form.:
C21H15F3N2O2
Mol. Mass.:
384.3512
SMILES:
FC(F)(F)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: