Target
N-lysine methyltransferase KMT5A
Ligand
BDBM50051121
Substrate
n/a
Meas. Tech.
ChEMBL_1450359 (CHEMBL3378196)
IC50
7900±n/a nM
Citation
 Ma, AYu, WLi, FBleich, RMHerold, JMButler, KVNorris, JLKorboukh, VTripathy, AJanzen, WPArrowsmith, CHFrye, SVVedadi, MBrown, PJJin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem 57:6822-33 (2014) [PubMed]  Article 
Target
Name:
N-lysine methyltransferase KMT5A
Synonyms:
KMT5A | KMT5A_HUMAN | N-lysine methyltransferase SETD8 | PRSET7 | SET domain-containing protein 8 (SetD8) | SET07 | SET8 | SETD8
Type:
Enzyme
Mol. Mass.:
42919.11
Organism:
Homo sapiens (Human)
Description:
Q9NQR1
Residue:
393
Sequence:
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
  
Inhibitor
Name:
BDBM50051121
Synonyms:
CHEMBL3318289
Type:
Small organic molecule
Emp. Form.:
C24H37N5O2
Mol. Mass.:
427.5829
SMILES:
COc1cc2nc(nc(NCCCCCN3CCCCC3)c2cc1OC)N1CCCC1
Structure:
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