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Target
Histone-lysine N-methyltransferase KMT5B
Ligand
BDBM50051117
Substrate
n/a
Meas. Tech.
ChEMBL_1450373 (CHEMBL3378210)
IC50
>100000±n/a nM
Citation
 Ma, A; Yu, W; Li, F; Bleich, RM; Herold, JM; Butler, KV; Norris, JL; Korboukh, V; Tripathy, A; Janzen, WP; Arrowsmith, CH; Frye, SV; Vedadi, M; Brown, PJ; Jin, J Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem 57:6822-33 (2014) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase KMT5B
Synonyms:
Histone-lysine N-methyltransferase SUV420H1 | KMT5B | KMT5B_HUMAN | Lysine N-methyltransferase 5B | Protein lysine methyltransferase SUV4-20H1 (SUV4-20H1) | SUV420H1 | Su(var)4-20 homolog 1 | Suppressor of variegation 4-20 homolog 1 | Suv4-20h1
Type:
Enzyme
Mol. Mass.:
99219.53
Organism:
Homo sapiens (Human)
Description:
Q4FZB7
Residue:
885
Sequence:
MKWLGESKNMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTLKAGKNAVERRSNRCNGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHFSKSDSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKNNATSNRKSSVGVKKNSKSRTLTRQSMSRIPASSNSTSSKLTHINNSRVPKKLKKPAKPLLSKIKLRNHCKRLEQKNASRKLEMGNLVLKEPKVVLYKNLPIKKDKEPEGPAQAAVASGCLTRHAAREHRQNPVRGAHSQGESSPCTYITRRSVRTRTNLKEASDIKLEPNTLNGYKSSVTEPCPDSGEQLQPAPVLQEEELAHETAQKGEAKCHKSDTGMSKKKSRQGKLVKQFAKIEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVGVPVSYTDCAPSPVGCSVVTSDSFKTKDSFRTAKSKKKRRITRYDAQLILENNSGIPKLTLRRRHDSSSKTNDQENDGMNSSKISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQLKRDEENRGSYTEGLHENGVCCSDPLSLLESRMEVDDYSQYEEESTDDSSSSEGDEEEDDYDDDFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
  
Inhibitor
Name:
BDBM50051117
Synonyms:
CHEMBL3318285
Type:
Small organic molecule
Emp. Form.:
C23H35N5O2
Mol. Mass.:
413.5563
SMILES:
COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: