Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50058941
Substrate
n/a
Meas. Tech.
ChEMBL_1456925 (CHEMBL3368142)
Ki
41±n/a nM
Citation
 Pala, N; Micheletto, L; Sechi, M; Aggarwal, M; Carta, F; McKenna, R; Supuran, CT Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. ACS Med Chem Lett 5:927-30 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50058941
Synonyms:
CHEMBL3326411
Type:
Small organic molecule
Emp. Form.:
C14H14F4N4O2S
Mol. Mass.:
378.345
SMILES:
NS(=O)(=O)c1c(F)c(F)c(c(F)c1F)-n1cc(nn1)C1CCCCC1
Structure:
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