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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50059190
Substrate
n/a
Meas. Tech.
ChEMBL_1460561 (CHEMBL3395593)
IC50
514±n/a nM
Citation
 Patel, S; Cohen, F; Dean, BJ; De La Torre, K; Deshmukh, G; Estrada, AA; Ghosh, AS; Gibbons, P; Gustafson, A; Huestis, MP; Le Pichon, CE; Lin, H; Liu, W; Liu, X; Liu, Y; Ly, CQ; Lyssikatos, JP; Ma, C; Scearce-Levie, K; Shin, YG; Solanoy, H; Stark, KL; Wang, J; Wang, B; Zhao, X; Lewcock, JW; Siu, M Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem 58:401-18 (2015) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50059190
Synonyms:
CHEMBL3393333
Type:
Small organic molecule
Emp. Form.:
C23H26F2N6O
Mol. Mass.:
440.4889
SMILES:
FC1(F)CCN(C1)c1cc(cc(Nc2cc(ccn2)C#N)n1)C1CCN(CC1)C1COC1
Structure:
Search PDB for entries with ligand similarity: