Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50135141
Substrate
n/a
Meas. Tech.
ChEMBL_1467847 (CHEMBL3412744)
Ki
6.3±n/a nM
Citation
 Buron, F; Mérour, JY; Akssira, M; Guillaumet, G; Routier, S Recent advances in the chemistry and biology of pyridopyrimidines. Eur J Med Chem 95:76-95 (2015) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50135141
Synonyms:
6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine | 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL145979
Type:
Small organic molecule
Emp. Form.:
C14H12Cl2N6
Mol. Mass.:
335.191
SMILES:
Nc1nc(N)c2cc(CNc3cc(Cl)ccc3Cl)cnc2n1
Structure:
Search PDB for entries with ligand similarity: