Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase SETD7
Ligand
BDBM50075073
Substrate
n/a
Meas. Tech.
ChEMBL_1473578 (CHEMBL3420688)
Ki
0.330000±n/a nM
Citation
 Kaniskan, HÜ; Konze, KD; Jin, J Selective inhibitors of protein methyltransferases. J Med Chem 58:1596-629 (2015) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SETD7
Synonyms:
Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | SET domain-containing protein 7/9 (Set7/9) | SET7 | SET9 | SETD7 | SETD7_HUMAN
Type:
Enzyme
Mol. Mass.:
40691.12
Organism:
Homo sapiens (Human)
Description:
Q8WTS6
Residue:
366
Sequence:
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
  
Inhibitor
Name:
BDBM50075073
Synonyms:
CHEMBL3414622
Type:
Small organic molecule
Emp. Form.:
C23H25F4N3O3S
Mol. Mass.:
499.522
SMILES:
Fc1cc(cc2CCNCc12)S(=O)(=O)N[C@H](Cc1cccc(c1)C(F)(F)F)C(=O)N1CCCC1 |r|
Structure:
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