Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50078123
Substrate
n/a
Meas. Tech.
ChEMBL_1471925 (CHEMBL3420840)
IC50
1.2±n/a nM
Citation
 Takahashi, HRiether, DBartolozzi, ABosanac, TBerger, VBinetti, RBroadwater, JChen, ZCrux, RDe Lombaert, SDave, RDines, JAFadra-Khan, TFlegg, AGarrigou, MHao, MHHuber, JHutzler, JMKerr, SKotey, ALiu, WLo, HYLoke, PLMahaney, PEMorwick, TMNapier, SOlague, APack, EPadyana, AKThomson, DSTye, HWu, LZindell, RMAbeywardane, ASimpson, T Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem 58:1669-90 (2015) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50078123
Synonyms:
CHEMBL3417526
Type:
Small organic molecule
Emp. Form.:
C24H26N8O2
Mol. Mass.:
458.5156
SMILES:
CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)cn1 |r|
Structure:
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