Target
Aldo-keto reductase family 1 member B7
Ligand
BDBM16452
Substrate
n/a
Meas. Tech.
ChEMBL_1475204 (CHEMBL3424959)
IC50
49±n/a nM
Citation
 Stefek, MSoltesova Prnova, MMajekova, MRechlin, CHeine, AKlebe, G Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. J Med Chem 58:2649-57 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B7
Synonyms:
ALD1_RAT | Akr1b14 | Akr1b7 | Aldehyde reductase | Aldo-keto reductase family 1 member B7 | Aldose reductase-like protein AKR1B14 | Aldose reductase-related protein 1
Type:
PROTEIN
Mol. Mass.:
36127.39
Organism:
Rattus norvegicus
Description:
ChEMBL_109605
Residue:
316
Sequence:
MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY
  
Inhibitor
Name:
BDBM16452
Synonyms:
(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | Alond | CHEMBL10372 | Xedia | Zopolrestat
Type:
Small organic molecule
Emp. Form.:
C19H12F3N3O3S
Mol. Mass.:
419.377
SMILES:
OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: