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Target
Somatostatin receptor subtype 3
Ligand
BDBM50091414
Substrate
n/a
Meas. Tech.
ChEMBL_1498171 (CHEMBL3583391)
IC50
2.5±n/a nM
Citation
 Shah, SK; He, S; Guo, L; Truong, Q; Qi, H; Du, W; Lai, Z; Liu, J; Jian, T; Hong, Q; Dobbelaar, P; Ye, Z; Sherer, E; Feng, Z; Yu, Y; Wong, F; Samuel, K; Madiera, M; Karanam, BV; Reddy, VB; Mitelman, S; Tong, SX; Chicchi, GG; Tsao, KL; Trusca, D; Feng, Y; Wu, M; Shao, Q; Trujillo, ME; Eiermann, GJ; Li, C; Pachanski, M; Fernandez, G; Nelson, D; Bunting, P; Morissette, P; Volksdorf, S; Kerr, J; Zhang, BB; Howard, AD; Zhou, YP; Pasternak, A; Nargund, RP; Hagmann, WK Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett 6:513-7 (2015) [PubMed]  Article 
Target
Name:
Somatostatin receptor subtype 3
Synonyms:
EMBL:AAV49129.1 | Ensembl:ENSCAFP00000037746 | SSTR3 | Somatostatin receptor subtype 3 | Uncharacterized protein
Type:
PROTEIN
Mol. Mass.:
45973.29
Organism:
Canis lupus familiaris
Description:
ChEMBL_109809
Residue:
425
Sequence:
MDTLGYPASVPTTLEPGNTSSAWPLDATVGNVSAAPSVAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSVAVWVASAVVVLPVVVFSGVPHGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVRAPSCQRRRHSERKVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPAGGPPEKTVEEQGEDREGEDREGEDGAGKQGEGKGMNGRVSLITQPGTSGQERPPSGKASKDKQPLPLEASAADKPGALHISYL
  
Inhibitor
Name:
BDBM50091414
Synonyms:
CHEMBL3582336
Type:
Small organic molecule
Emp. Form.:
C27H24FN9O2
Mol. Mass.:
525.537
SMILES:
CCn1cc(cn1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cn1)c1nn(C)c(=O)o1 |r|
Structure:
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