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Target
Bromodomain-containing protein 2
Ligand
BDBM50092311
Substrate
n/a
Meas. Tech.
ChEMBL_1498012 (CHEMBL3584941)
Ki
12±n/a nM
Citation
 Ran, X; Zhao, Y; Liu, L; Bai, L; Yang, CY; Zhou, B; Meagher, JL; Chinnaswamy, K; Stuckey, JA; Wang, S Structure-Based Design of¿-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem 58:4927-39 (2015) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 2
Synonyms:
BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
88085.95
Organism:
Homo sapiens (Human)
Description:
P25440
Residue:
801
Sequence:
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
  
Inhibitor
Name:
BDBM50092311
Synonyms:
CHEMBL3581662
Type:
Small organic molecule
Emp. Form.:
C28H25N5O2
Mol. Mass.:
463.5304
SMILES:
CCc1[nH]nc(c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)-c1ccccc1 |(1.05,4.4,;.13,3.57,;-1.35,4.05,;-1.84,5.52,;-3.39,5.51,;-3.86,4.03,;-2.59,3.15,;-2.58,1.59,;-3.83,.85,;-3.83,-.63,;-2.58,-1.37,;-1.27,-.63,;,-1.37,;1.27,-.63,;2.56,-1.37,;3.87,-.63,;5.21,-1.41,;5.36,-2.94,;4.43,-3.77,;6.87,-3.26,;7.65,-1.92,;6.61,-.77,;6.86,.45,;3.87,.85,;5.21,1.63,;5.21,2.88,;2.56,1.59,;1.27,.85,;-1.27,.85,;-5.33,3.53,;-5.75,2.04,;-7.25,1.66,;-8.34,2.77,;-7.92,4.26,;-6.41,4.65,)|
Structure:
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