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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50095436
Substrate
n/a
Meas. Tech.
ChEMBL_1504110 (CHEMBL3591484)
IC50
60±n/a nM
Citation
 Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett 6:655-9 (2015) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50095436
Synonyms:
CHEMBL3589043
Type:
Small organic molecule
Emp. Form.:
C23H29N5O2
Mol. Mass.:
407.5087
SMILES:
CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(c2)C(=O)N(C)C)cc1
Structure:
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