Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50095464
Substrate
n/a
Meas. Tech.
ChEMBL_1504266 (CHEMBL3592269)
IC50
9200±n/a nM
Citation
 Lim, JAltman, MDBaker, JBrubaker, JDChen, HChen, YFischmann, TGibeau, CKleinschek, MALeccese, ELesburg, CMaclean, JKMoy, LYMulrooney, EFPresland, JRakhilina, LSmith, GFSteinhuebel, DYang, R Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett 6:683-8 (2015) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50095464
Synonyms:
CHEMBL3590437 | US9649308, Example 39
Type:
Small organic molecule
Emp. Form.:
C14H16N8O3
Mol. Mass.:
344.3286
SMILES:
Cn1cc(NC(=O)c2cnn3ccc(OCCN)nc23)c(n1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: