Reaction Details Report a problem with these data
Target
Histone chaperone ASF1A
Ligand
BDBM50101587
Substrate
n/a
Meas. Tech.
ChEMBL_1462421 (CHEMBL3395843)
IC50
>12000±n/a nM
Citation
 Miknis, GF; Stevens, SJ; Smith, LE; Ostrov, DA; Churchill, ME Development of novel Asf1-H3/H4 inhibitors. Bioorg Med Chem Lett 25:963-8 (2015) [PubMed]  Article 
Target
Name:
Histone chaperone ASF1A
Synonyms:
ASF1A | ASF1A_HUMAN | Anti-silencing function protein 1 homolog A | CCG1-interacting factor A | CIA | HSPC146 | Histone chaperone ASF1A | hAsf1 | hAsf1a | hCIA
Type:
PROTEIN
Mol. Mass.:
22950.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109562
Residue:
204
Sequence:
MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM
  
Inhibitor
Name:
BDBM50101587
Synonyms:
CHEMBL3394925
Type:
Small organic molecule
Emp. Form.:
C23H20BrN3O4
Mol. Mass.:
482.327
SMILES:
COc1cc(\C=N\N(C)C(=O)c2ccc(NC(=O)c3ccccc3)cc2)cc(Br)c1O
Structure:
Search PDB for entries with ligand similarity: