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TargetHistone chaperone ASF1A
LigandBDBM50101746
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1462421
IC50 32000±n/a nM
Citation Miknis, GFStevens, SJSmith, LEOstrov, DAChurchill, ME Development of novel Asf1-H3/H4 inhibitors. Bioorg Med Chem Lett25:963-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone chaperone ASF1A
Name:Histone chaperone ASF1A
Synonyms:ASF1A | Anti-silencing function protein 1 homolog A | CCG1-interacting factor A | CIA | HSPC146 | Histone chaperone ASF1A | hAsf1 | hAsf1a | hCIA
Type:PROTEIN
Mol. Mass.:22950.75
Organism:Homo sapiens (Human)
Description:ChEMBL_109562
Residue:204
Sequence:
MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSV
LVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTET
ELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALP
SASKGWSTSENSLNVMLESHMDCM
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  Blast E-value cutoff:
BDBM50101746
NameBDBM50101746
Synonyms:CHEMBL3394891
TypeSmall organic molecule
Emp. Form.C17H15BrClN3O4
Mol. Mass.440.676
SMILESCOc1cc(\C=N\NC(=O)c2ccc(NC(=O)CCl)cc2)cc(Br)c1O
Structure
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