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Target
Alpha-synuclein
Ligand
BDBM50103971
Substrate
n/a
Meas. Tech.
ChEMBL_1505256 (CHEMBL3594881)
Ki
150±n/a nM
Citation
 Chu, W; Zhou, D; Gaba, V; Liu, J; Li, S; Peng, X; Xu, J; Dhavale, D; Bagchi, DP; d'Avignon, A; Shakerdge, NB; Bacskai, BJ; Tu, Z; Kotzbauer, PT; Mach, RH Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils. J Med Chem 58:6002-17 (2015) [PubMed]  Article 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM50103971
Synonyms:
CHEMBL3593897
Type:
Small organic molecule
Emp. Form.:
C22H19N3O
Mol. Mass.:
341.4058
SMILES:
CN(C)c1ccc(\C=C2/C(=O)N(c3ccccc23)c2ccncc2)cc1
Structure:
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