Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50104776
Substrate
n/a
Meas. Tech.
ChEMBL_1508094 (CHEMBL3599695)
Ki
0.310000±n/a nM
Citation
 Barresi, E; Bruno, A; Taliani, S; Cosconati, S; Da Pozzo, E; Salerno, S; Simorini, F; Daniele, S; Giacomelli, C; Marini, AM; La Motta, C; Marinelli, L; Cosimelli, B; Novellino, E; Greco, G; Da Settimo, F; Martini, C Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides. J Med Chem 58:6081-92 (2015) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50104776
Synonyms:
CHEMBL3597377
Type:
Small organic molecule
Emp. Form.:
C26H26N2O2
Mol. Mass.:
398.4968
SMILES:
CCCN(CCC)C(=O)C(=O)c1c([nH]c2ccccc12)-c1ccc2ccccc2c1
Structure:
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