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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Ligand
BDBM50105912
Substrate
n/a
Meas. Tech.
ChEMBL_1508025 (CHEMBL3599515)
IC50
1400±n/a nM
Citation
 Yadav, RR; Sharma, S; Joshi, P; Wani, A; Vishwakarma, RA; Kumar, A; Bharate, SB Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. Bioorg Med Chem Lett 25:2948-52 (2015) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Synonyms:
DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2
Type:
PROTEIN
Mol. Mass.:
66690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508025
Residue:
601
Sequence:
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
  
Inhibitor
Name:
BDBM50105912
Synonyms:
CHEMBL3133762
Type:
Small organic molecule
Emp. Form.:
C17H16BrN5O2
Mol. Mass.:
402.245
SMILES:
Nc1nccc(n1)-c1cn(C(=O)N2CCOCC2)c2ccc(Br)cc12
Structure:
Search PDB for entries with ligand similarity: