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Reaction Details
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TargetAdenosine A3 receptor
LigandBDBM50116878
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515686
Ki 16±n/a nM
Citation Tosh, DKCrane, SChen, ZPaoletta, SGao, ZGGizewski, EAuchampach, JASalvemini, DJacobson, KA Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy. ACS Med Chem Lett6:804-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine A3 receptor
Name:Adenosine A3 receptor
Synonyms:A3AR | Adenosine receptor A3
Type:PROTEIN
Mol. Mass.:36460.91
Organism:Mus musculus
Description:ChEMBL_1515686
Residue:319
Sequence:
MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADI
AVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYR
TVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVF
FSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLF
ALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRA
VRLCQTSDSLDSNMEQTTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50116878
NameBDBM50116878
Synonyms:CHEMBL3612940
TypeSmall organic molecule
Emp. Form.C22H22ClN5O3S
Mol. Mass.471.96
SMILES[H][C@]12C[C@]1([C@@H](O)[C@@H](O)[C@@H]2n1cnc2c(NCC)cc(nc12)C#Cc1ccc(Cl)s1)C(=O)NC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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