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Target
Carbonic anhydrase 7
Ligand
BDBM50117677
Substrate
n/a
Meas. Tech.
ChEMBL_1515207 (CHEMBL3614554)
Ki
3.1±n/a nM
Citation
 Buemi, MR; De Luca, L; Ferro, S; Bruno, E; Ceruso, M; Supuran, CT; Pospí?ilová, K; Brynda, J; Rezácová, P; Gitto, R Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur J Med Chem 102:223-32 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50117677
Synonyms:
CHEMBL3613778
Type:
Small organic molecule
Emp. Form.:
C17H18N2O4S
Mol. Mass.:
346.401
SMILES:
COc1ccc2CN(CCc2c1)C(=O)c1ccc(cc1)S(N)(=O)=O
Structure:
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