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Target
Carbonic anhydrase 2
Ligand
BDBM50117675
Substrate
n/a
Meas. Tech.
ChEMBL_1515206 (CHEMBL3614553)
Ki
7.7±n/a nM
Citation
 Buemi, MR; De Luca, L; Ferro, S; Bruno, E; Ceruso, M; Supuran, CT; Pospí?ilová, K; Brynda, J; Rezácová, P; Gitto, R Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur J Med Chem 102:223-32 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50117675
Synonyms:
CHEMBL3613780
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3S
Mol. Mass.:
316.375
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)N1CCc2ccccc2C1
Structure:
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