Reaction Details Report a problem with these data
Target
Acid-sensing ion channel 5
Ligand
BDBM50124574
Substrate
n/a
Meas. Tech.
ChEMBL_1520854 (CHEMBL3626239)
EC50
2800000±n/a nM
Citation
 Hendriks, CM; Penning, TM; Zang, T; Wiemuth, D; Gründer, S; Sanhueza, IA; Schoenebeck, F; Bolm, C Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities. Bioorg Med Chem Lett 25:4437-40 (2015) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 5
Synonyms:
ASIC5_RAT | Accn5 | Accn5 | Acid-sensing ion channel 5 | Amiloride-sensitive cation channel 5 | Asic5 | Blinac | Brain-liver-intestine amiloride-sensitive Na(+) channel
Type:
PROTEIN
Mol. Mass.:
56474.87
Organism:
Rattus norvegicus
Description:
ChEMBL_109894
Residue:
495
Sequence:
MEHTEKSKGPAEKGLLGKIRRYLSKRPLPSPTDRKKFDHDFAISTSFHGIHNIAQNQNKVRKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFLLPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYLFTSFYWVFIFFLLKILEMIQRTSPPQTV
  
Inhibitor
Name:
BDBM50124574
Synonyms:
CHEMBL3623737
Type:
Small organic molecule
Emp. Form.:
C13H10F5NO2S
Mol. Mass.:
339.281
SMILES:
OC(=O)c1cccc(Nc2ccc(cc2)S(F)(F)(F)(F)F)c1
Structure:
Search PDB for entries with ligand similarity: