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Target
Carbonic anhydrase 12
Ligand
BDBM50133403
Substrate
n/a
Meas. Tech.
ChEMBL_1525821 (CHEMBL3635735)
Ki
94±n/a nM
Citation
 La Regina, G; Coluccia, A; Famiglini, V; Pelliccia, S; Monti, L; Vullo, D; Nuti, E; Alterio, V; De Simone, G; Monti, SM; Pan, P; Parkkila, S; Supuran, CT; Rossello, A; Silvestri, R Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J Med Chem 58:8564-72 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50133403
Synonyms:
CHEMBL3632839
Type:
Small organic molecule
Emp. Form.:
C20H17NO5S
Mol. Mass.:
383.418
SMILES:
NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C(O)c1ccc(cc1)C(O)=O
Structure:
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