Reaction Details Report a problem with these data
Target
Carbonic anhydrase, alpha family
Ligand
BDBM11638
Substrate
n/a
Meas. Tech.
ChEMBL_1543854 (CHEMBL3749744)
Ki
873±n/a nM
Citation
 Vullo, D; Bhatt, A; Mahon, BP; McKenna, R; Supuran, CT Sulfonamide inhibition studies of thea-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorg Med Chem Lett 26:401-5 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase, alpha family
Synonyms:
Carbonic anhydrase, alpha family
Type:
PROTEIN
Mol. Mass.:
35831.01
Organism:
Thiomicrospira crunogena (strain XCL-2)
Description:
ChEMBL_109899
Residue:
315
Sequence:
MKKRFSFIFIFLVALPLYSANNVAAPLIDLGAEAKKQAQKSAATQSAVPEKESATKVAEKQKEPEEKAKPEPKKPPHWGYFGEEGPQYWGELAPEFSTCKTGKNQSPINLKPQTAVGTTSLPGFDVYYRETALKLINNGHTLQVNIPLGSYIKINGHRYELLQYHFHTPSEHQRDGFNYPMEMHLVHKDGDGNLAVIAILFQEGEENETLAKLMSFLPQTLKKQEIHESVKIHPAKFFPADKKFYKYSGSLTTPPCSEGVYWMVFKQPIQASVTQLEKMHEYLGSNARPVQRQNARTLLKSWPDRNRANTVYEFY
  
Inhibitor
Name:
BDBM11638
Synonyms:
CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide | SULPIRIDE,(+) | SULPIRIDE,(-) | Sulpiride | Sulpiride, SLP | Sulpiride-R | US10172837, Sulpiride
Type:
Small organic molecule
Emp. Form.:
C15H23N3O4S
Mol. Mass.:
341.426
SMILES:
CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Structure:
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