Reaction Details Report a problem with these data
Target
Testis-specific serine/threonine-protein kinase 3
Ligand
BDBM50135286
Substrate
n/a
Meas. Tech.
ChEMBL_1543473 (CHEMBL3750192)
IC50
>5000±n/a nM
Citation
 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem 24:521-44 (2016) [PubMed]  Article 
Target
Name:
Testis-specific serine/threonine-protein kinase 3
Synonyms:
SPOGA3 | SPOGA3 | STK22C | Serine/threonine-protein kinase 22C | TSK-3 | TSSK-3 | TSSK3 | TSSK3_HUMAN | Testis-specific kinase 3 | Testis-specific serine/threonine-protein kinase 3
Type:
PROTEIN
Mol. Mass.:
30102.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109599
Residue:
268
Sequence:
MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST
  
Inhibitor
Name:
BDBM50135286
Synonyms:
CHEMBL3745885
Type:
Small organic molecule
Emp. Form.:
C22H15F2N5O3S
Mol. Mass.:
467.448
SMILES:
Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F
Structure:
Search PDB for entries with ligand similarity: