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TargetAdenosine receptor A2
LigandBDBM50139773
Substrate/Competitorn/a
Meas. Tech.ChEBML_1553861
Ki 0.200000±n/a nM
Citation Zhou, GAslanian, RGallo, GKhan, TKuang, RPurakkattle, BDe Ruiz, MStamford, ATing, PWu, HWang, HXiao, DYu, TZhang, YMullins, DHodgson, R Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists. Bioorg Med Chem Lett26:1348-54 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A2
Name:Adenosine receptors; A1 & A2a
Synonyms:A2A adenosine receptor (hA2A) | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44716.46
Organism:Homo sapiens (Human)
Description:P29274
Residue:412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50139773
NameBDBM50139773
Synonyms:CHEMBL3765379 | US10138212, Example 101
TypeSmall organic molecule
Emp. Form.C20H14F3N5O2
Mol. Mass.413.3527
SMILESNc1nc(C(=O)NCc2cccc3cccnc23)c2cccc(OC(F)(F)F)c2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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