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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50151156
Substrate
n/a
Meas. Tech.
ChEMBL_1558879 (CHEMBL3772811)
IC50
17300±n/a nM
Citation
 Nuzzi, A; Fiasella, A; Ortega, JA; Pagliuca, C; Ponzano, S; Pizzirani, D; Bertozzi, SM; Ottonello, G; Tarozzo, G; Reggiani, A; Bandiera, T; Bertozzi, F; Piomelli, D Potenta-amino-ß-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. Eur J Med Chem 111:138-59 (2016) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM50151156
Synonyms:
CHEMBL3769863
Type:
Small organic molecule
Emp. Form.:
C16H28N2O3
Mol. Mass.:
296.4051
SMILES:
CC1(C)NC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1 |r|
Structure:
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