Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50138301
Substrate
n/a
Meas. Tech.
ChEMBL_1560591 (CHEMBL3777323)
Ki
2.0±n/a nM
Citation
 Dosa, PI; Amin, EA Tactical Approaches to Interconverting GPCR Agonists and Antagonists. J Med Chem 59:810-40 (2016) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50138301
Synonyms:
4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}-piperazin-1-yl)-3-(4-chloro-benzyl)-4-oxo-butyryl]-piperazine-1-carboxylic acid tert-butyl ester | CHEMBL124954
Type:
Small organic molecule
Emp. Form.:
C36H50ClN5O5
Mol. Mass.:
668.266
SMILES:
CCN(C(C)c1ccccc1N1CCN(CC1)C(=O)[C@H](CC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)Cc1ccc(Cl)cc1)C(C)=O
Structure:
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