Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM50156282
Substrate
n/a
Meas. Tech.
ChEMBL_1563729 (CHEMBL3784030)
IC50
2.0±n/a nM
Citation
 Huang, AJayaraman, LFura, AVite, GDTrainor, GLGottardis, MMSpires, TESpires, VMRizzo, CAObermeier, MTElzinga, PATodderud, GFan, YNewitt, JABeyer, SMZhu, YWarrack, BMGoodenough, AKTebben, AJDoweyko, AMGold, DLBalog, A Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett 7:40-5 (2016) [PubMed]  Article 
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
17-alpha-hydroxyprogesterone aldolase | CP17A_MACFA | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
PROTEIN
Mol. Mass.:
57634.34
Organism:
Macaca fascicularis
Description:
ChEMBL_116757
Residue:
508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
  
Inhibitor
Name:
BDBM50156282
Synonyms:
CHEMBL3780847
Type:
Small organic molecule
Emp. Form.:
C24H31NO
Mol. Mass.:
349.509
SMILES:
[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)C1CC[C@@]1(C)C2CC=C1c1cccnc1 |r,c:22,t:3|
Structure:
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