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Target
Peptidyl-prolyl cis-trans isomerase D
Ligand
BDBM50169545
Substrate
n/a
Meas. Tech.
ChEMBL_1578413 (CHEMBL3808128)
Ki
1330±n/a nM
Citation
 Valasani, KR; Sun, Q; Fang, D; Zhang, Z; Yu, Q; Guo, Y; Li, J; Roy, A; ShiDu Yan, S Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aß-Mediated Mitochondrial Dysfunction. ACS Med Chem Lett 7:294-9 (2016) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase D
Synonyms:
40 kDa peptidyl-prolyl cis-trans isomerase | CYP-40 | CYP40 | CYPD | Cyclophilin D (CypD) | Cyclophilin-40 | Cyclophilin-related protein | PPID | PPID_HUMAN | PPIase D | Peptidyl-prolyl cis-trans isomerase D | Rotamase D
Type:
Protein
Mol. Mass.:
40766.62
Organism:
Homo sapiens (Human)
Description:
Q08752
Residue:
370
Sequence:
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
  
Inhibitor
Name:
BDBM50169545
Synonyms:
CHEMBL3805631
Type:
Small organic molecule
Emp. Form.:
C22H22N4O4S2
Mol. Mass.:
470.564
SMILES:
CC(C)COc1ccc(cc1C#N)-c1nc(C)c(s1)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure:
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