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Target
D-amino-acid oxidase
Ligand
BDBM31148
Substrate
n/a
Meas. Tech.
ChEMBL_1577591 (CHEMBL3807135)
IC50
94±n/a nM
Citation
 Xie, D; Lu, J; Xie, J; Cui, J; Li, TF; Wang, YC; Chen, Y; Gong, N; Li, XY; Fu, L; Wang, YX Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor. Eur J Med Chem 117:19-32 (2016) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | DAMOX | Dao | Dao1 | OXDA_RAT
Type:
Homodimer
Mol. Mass.:
38824.91
Organism:
Rattus norvegicus (rat)
Description:
Recombinant rat DAAO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
346
Sequence:
MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
  
Inhibitor
Name:
BDBM31148
Synonyms:
3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1
Type:
Small organic molecule
Emp. Form.:
C9H7NO2
Mol. Mass.:
161.1574
SMILES:
Oc1cc2ccccc2[nH]c1=O
Structure:
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