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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50172063
Substrate
n/a
Meas. Tech.
ChEMBL_1577192 (CHEMBL3807566)
IC50
3370±n/a nM
Citation
 Yang, YS; Yang, B; Zou, Y; Li, G; Zhu, HL Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors. Bioorg Med Chem 24:3052-3061 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-raf | BRAF_MOUSE | Braf | Proto-oncogene B-Raf | Serine/threonine-protein kinase B-raf
Type:
PROTEIN
Mol. Mass.:
88789.83
Organism:
Mus musculus
Description:
ChEMBL_105657
Residue:
804
Sequence:
MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
  
Inhibitor
Name:
BDBM50172063
Synonyms:
CHEMBL3805849
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2N2O2
Mol. Mass.:
425.307
SMILES:
Clc1ccc(cc1Cl)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:11|
Structure:
Search PDB for entries with ligand similarity: