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Target
Cytochrome P450 2C8
Ligand
BDBM50175303
Substrate
n/a
Meas. Tech.
ChEMBL_1581102 (CHEMBL3813400)
IC50
180±n/a nM
Citation
 Fader, L; Brault, M; Desjardins, J; Dansereau, N; Lamorte, L; Tremblay, S; Bilodeau, F; Bordeleau, J; Duplessis, M; Gorys, V; Gillard, J; Gleason, JL; James, C; Joly, MA; Kuhn, C; Llinas-Brunet, M; Luo, L; Morency, L; Morin, S; Parisien, M; Poirier, M; Thibeault, C; Trinh, T; Sturino, C; Srivastava, S; Yoakim, C; Franti, M Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus. ACS Med Chem Lett 7:525-30 (2016) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C8
Synonyms:
CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:
Protein
Mol. Mass.:
55839.23
Organism:
Homo sapiens (Human)
Description:
P10632
Residue:
490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
  
Inhibitor
Name:
BDBM50175303
Synonyms:
CHEMBL3810042
Type:
Small organic molecule
Emp. Form.:
C23H20F3N5O3S
Mol. Mass.:
503.497
SMILES:
CC(C)OC(c1nc(c[nH]1)-n1ccc(NC(=O)c2cscn2)cc1=O)c1cccc(c1)C(F)(F)F
Structure:
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