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Target
Cholesteryl ester transfer protein
Ligand
BDBM50178693
Substrate
n/a
Meas. Tech.
ChEMBL_1583725 (CHEMBL3815812)
IC50
7000±n/a nM
Citation
 Jiang, J; Finlay, H; Johnson, JA; Harikrishnan, L; Kamau, M; Qiao, J; Wang, T; Adam, L; Taylor, D; Yang, R; Sleph, P; Chen, AYA; Yin, X; Wexler, R; Salvati, ME Discovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors. Bioorg Med Chem Lett 26:3278-3281 (2016) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50178693
Synonyms:
CHEMBL3814330
Type:
Small organic molecule
Emp. Form.:
C28H17ClF8N2O
Mol. Mass.:
584.888
SMILES:
Fc1cc(cc(c1)[C@](Cc1ccccc1)(NC(=O)c1ccc(F)c(c1)C(F)(F)F)c1ccc(Cl)cn1)C(F)(F)F |r|
Structure:
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