Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50185427
Substrate
n/a
Meas. Tech.
ChEMBL_1588017 (CHEMBL3824952)
EC50
1900±n/a nM
Citation
 Panarese, JDCho, HPAdams, JJNance, KDGarcia-Barrantes, PMChang, SMorrison, RDBlobaum, ALNiswender, CMStauffer, SRConn, PJLindsley, CW Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorg Med Chem Lett 26:3822-5 (2016) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50185427
Synonyms:
CHEMBL3823130
Type:
Small organic molecule
Emp. Form.:
C18H15FN4O
Mol. Mass.:
322.3363
SMILES:
Cn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
Structure:
Search PDB for entries with ligand similarity: