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Target
Histone deacetylase 2
Ligand
BDBM50189903
Substrate
n/a
Meas. Tech.
ChEMBL_1591001 (CHEMBL3830979)
IC50
62±n/a nM
Citation
 Wagner, FF; Weïwer, M; Steinbacher, S; Schomburg, A; Reinemer, P; Gale, JP; Campbell, AJ; Fisher, SL; Zhao, WN; Reis, SA; Hennig, KM; Thomas, M; Müller, P; Jefson, MR; Fass, DM; Haggarty, SJ; Zhang, YL; Holson, EB Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem 24:4008-4015 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50189903
Synonyms:
CHEMBL3828396 | US11572368, Compound 54
Type:
Small organic molecule
Emp. Form.:
C18H19FN2O2
Mol. Mass.:
314.3541
SMILES:
Nc1ccc(cc1NC(=O)C1CCOCC1)-c1ccc(F)cc1
Structure:
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