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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50197279
Substrate
n/a
Meas. Tech.
ChEBML_1619372
IC50
130±n/a nM
Citation
 Xu, Z; Xu, X; O'Laoi, R; Ma, H; Zheng, J; Chen, S; Luo, L; Hu, Z; He, S; Li, J; Zhang, H; Zhang, X Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold. Bioorg Med Chem 24:5861-5872 (2016) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50197279
Synonyms:
CHEMBL3914927
Type:
Small organic molecule
Emp. Form.:
C24H20N4O
Mol. Mass.:
380.4418
SMILES:
Cn1nccc1-c1ccc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1
Structure:
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