Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50197286
Substrate
n/a
Meas. Tech.
ChEBML_1619372
IC50
44±n/a nM
Citation
 Xu, ZXu, XO'Laoi, RMa, HZheng, JChen, SLuo, LHu, ZHe, SLi, JZhang, HZhang, X Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold. Bioorg Med Chem 24:5861-5872 (2016) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50197286
Synonyms:
CHEMBL3965048
Type:
Small organic molecule
Emp. Form.:
C26H18FN3O2
Mol. Mass.:
423.4384
SMILES:
Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3-c4ccccc4C(=O)c3c2)cc1F
Structure:
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