Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50204072
Substrate
n/a
Meas. Tech.
ChEMBL_1626049 (CHEMBL3868518)
EC50
8.0±n/a nM
Citation
 Kick, EKBusch, BBMartin, RStevens, WCBollu, VXie, YBoren, BCNyman, MCNanao, MHNguyen, LPlonowski, ASchulman, IGYan, GZhang, HHou, XValente, MNNarayanan, RBehnia, KRodrigues, ADBrock, BSmalley, JCantor, GHLupisella, JSleph, PGrimm, DOstrowski, JWexler, RRKirchgessner, TMohan, R Discovery of Highly Potent Liver X Receptorß Agonists. ACS Med Chem Lett 7:1207-1212 (2016) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50204072
Synonyms:
CHEMBL3945199 | US10543183, Compound 12 | US10945978, Compound 12
Type:
Small organic molecule
Emp. Form.:
C29H28Cl2F2N2O4S
Mol. Mass.:
609.511
SMILES:
CC(C)(O)c1cn(c(n1)C(C)(C)c1c(Cl)cccc1Cl)-c1ccc(cc1F)-c1cc(F)c(CO)c(c1)S(C)(=O)=O
Structure:
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